SUN2 (Sad1 and UNC84 domain containing 2), found in the nuclear membrane of cells, is an essential protein for many cellular processes. SUN plays a large role in the organization of multi-nucleated muscle cells, and dysregulation of SUN can cause muscular dystrophy among other diseases...Read more
Autophagosomes play a crucial role in recycling, by degrading cellular components and providing building blocks for renewal och cell components. Last year, we published a post about autophagy, which was the subject of the 2016 Nobel Prize in Physiology and Medicine.
We show, for the first time, images of HPA antibodies that co-localize with the autophagosomes. These membrane bound vesicles are involved in degradation of cellular constituents through a process called autophagy. The protein detected is localized to the autophagosomes (green) in SH-SY5Y cells, a human neuroblastoma cell line from neural tissue...Read more
Diurnal cycle influence biological processes in all organisms, on a molecular level, through regulators of the circadian clock. The Nuclear factor interleukin-3-regulated protein is a component of the circadian clock in humans that also fluctuates with the seasons. The Human Protein Atlas team has stained in A-431 cells NFIL3 (green) in nuclear bodies with DNA (blue) and microtubules (red)...Read more
Distinct mitotic substages have been identified during cell cycle progression. The different subphases are characterised by variation in protein abundance and degree of phosphorylation...Read more
TPX2 was identified in 1997 as a 100 kDa nuclear protein. In cells TPX2, a is a microtubule nucleation factor that translocates from the nucleus - where it resides during interphase - to the mitotic spindle during mitosis.
The mitotic spindle forms when chromosomes are ready to segregate during cell division and not surprisingly this protein is also found in this specific compartment of the cell! TPX2 is required for the correct formation of the kinetochores that is crucial for the attachment of microtubules, enabling the sister chromatids to be pulled apart. Due to its function TPX2 expression is cell-cycle dependent...Read more