SUN2 (Sad1 and UNC84 domain containing 2), found in the nuclear membrane of cells, is an essential protein for many cellular processes. SUN plays a large role in the organization of multi-nucleated muscle cells, and dysregulation of SUN can cause muscular dystrophy among other diseases...Read more
Malignant melanoma originates from the pigment-producing melanocytes in the epidermal basal layer, and is considered to develop in a multi-step process. By using a systems level approach to analyze the melanoma proteome with respect to clinical outcome based on genome-wide transcriptomics, 205 genes were found to be associated with prognostic outcome...Read more
Autophagosomes play a crucial role in recycling, by degrading cellular components and providing building blocks for renewal och cell components. Last year, we published a post about autophagy, which was the subject of the 2016 Nobel Prize in Physiology and Medicine.
We show, for the first time, images of HPA antibodies that co-localize with the autophagosomes. These membrane bound vesicles are involved in degradation of cellular constituents through a process called autophagy. The protein detected is localized to the autophagosomes (green) in SH-SY5Y cells, a human neuroblastoma cell line from neural tissue...Read more
Research-used antibodies continue to be important tools for detection, analysis and characterization of proteins. As reagents, and used in combination with technological platforms, antibodies enable researchers to explore the human body and understand how building-blocks like proteins are produced, distributed and diminished, as well as monitor alteration in time, space and during disease development...Read more
March 28, 2019 - March 29, 2019
On March 29th, 2019, Mathias Uhlén will give a keynote on "The Human Protein Atlas - implications for human biology, drug development and precision medicine" at the International Rouen P2M Symposium on Precision Medicine "Pathways to Precision Medicine".