Urothelial cancer, also called bladder cancer, typically presents in patients over 50 years and is approximately three times as common in males compared to females. Tobacco is considered an important risk factor for developing bladder cancer. By using a systems level approach to analyze the urothelial cancer proteome based on clinical metadata and genome-wide transcriptomics data, 1093 genes were found to be associated with prognostic outcome...Read more
Some proteins are expressed periodically during a specific stage of the cell cycle or as a response to various stimuli. As a result, at any given time some cells express the protein of interest and some do not. In the Cell Atlas we denote these images as single-cell variation (SCV). An example of a protein with such variations is CCNB1.
CCNB1, shown here in U-251 MG cells, is essential for cellular proliferation. The abundance of CCNB1 oscillates across the cell cycle, and peaks during G2/M phase. CCNB1 is expressed in the cytoplasm during interphase and translocate to the nucleus during G2/M transition...Read more
Gliomas are a group of brain tumors that originate from different types of glial cells in the central nervous system. The prognosis for glioma is generally poor due to limited possibilities for curative treatment. By using a systems level approach to analyze the glioma proteome with respect to clinical outcome based on genome-wide transcriptomics, 263 genes were found to be associated with prognostic outcome...Read more
PepTalk: The Protein Science Week is one of the largest annual gatherings of protein science researchers in the world. PepTalk attracts nearly 1,300 experts from academia, biotech and pharma who come together for one week of intensive learning and networking to discover new opportunities, apply alternative solutions, and develop promising partnerships. This event covers a wide spectrum of applied protein sciences with emphasis on upstream R&D engineering to downstream biologics production...Read more